Contains a blend of ingredients shown to improve mood and reduce stress†
Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (1-3).† GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (4-6).
L-theanine: Amino acid that acts as a glutamate receptor antagonist (7)†. In a randomized, double-blind, placebo-controlled study, L-theanine was shown to significantly reduce stress (8)†.
5-HTP (from Griffonia simplicifolia seed extract): 5-hydroxytryptophan (5-HTP) crosses the blood-brain barrier and is a precursor to serotonin and melatonin (9).† Serotonin is important for regulating mood and sleep-wake function (10). In a randomized, double-blind study, 5-HTP was shown to significantly improve mood (11).†
Vitamins B and C: Active forms of vitamin B6, folate, B12, and C are important for serotonin synthesis (12-16).†
References
1. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
2. Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
3. Kletke O, et al. PLoS One. 2013;8(4):e61733.
4. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
5. Mohler H. Neuropharmacology. 2012;62(1):42-53.
6. Saper C, et al. Nature. 2005;437(7063):1257-63.
7. Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683-2686.
8. Kimura K, et al. Biol Psychol. 2007; 74(1):39-45.
9. Shaw K, et al. Cochrane Database Syst Rev. 2002;(1):CD003198.
10. Monti J. Sleep Med Rev. 2011;15(4):269-81.
11. Jangid P, et al. Asian J Psychiatr. 2013;6(1):29-34.
12. Dakshinamurti K, et al. Ann N Y Acad Sci. 1990;585:128-44.
13. Bottiglieri T. Psychiatr Clin North Am. 2013;36(1):1-13.
14. Stahl S. J Clin Psychiatry. 2008;69(9):1352-3.
15. Antoniades C, et al. Circulation. 2006;114(11):1193-201.
16. May J, et al. Brain Res Bull. 2013;90:35-42.
Take 1-3 capsules one to two times daily or as directed by your healthcare provider
If you are pregnant or nursing, consult your healthcare provider before use.
Serving Size: 3 Capsules
Servings Per Container: 40
| Amount Per Serving | % Daily Value | |
|---|---|---|
| Vitamin C (as ascorbic acid) | 40 mg | 67% |
| Vitamin B6 (as pyridoxal 5'-phosphate) | 9 mg | 450% |
| Folate (from (6S)-5-methyltetra-hydrofolic acid, glucosamine salt‡) | 200 mcg | 50% |
| Vitamin B12 (as methylcobalamin) | 30 mcg | 500% |
| Magnesium (as magnesium bisglycinate chelate) | 50 mg | 13% |
| Zinc (as zinc bisglycinate chelate) | 10 mg | 67% |
| Selenium (as L-selenomethionine) | 70 mcg | 100% |
| Proprietary Blend: | 950 mg | ** |
| Taurine, L-theanine, 5-hydroxytryptophan (from Griffonia simplicifolia seed extract) |
** Daily Value not established.
OTHER INGREDIENTS: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, and Magnesium stearate (vegetable source).
‡ This product uses Gnosis S.p.A's (6S)-5-methyltetrahydrofolic acid, glucosamine salt (Quatrefolic®) and is protected by U.S. Patent No. 7,947,662. Quatrefolic is a registered trademark of Gnosis S.p.A., Milan, Italy.
